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When an email bounces, a recipient marks your email as spam, or someone unsubscribes, we automatically add them to your suppression list. Subsequent send attempts to that address are rejected.

Suppression types

What happens when you send to a suppressed address

The send request returns 422 with a typed error:
Your agent should handle this gracefully - for example, by noting that the contact is unreachable and trying an alternative communication channel. Suppressions are one part of maintaining good deliverability. For the full picture — warm-up strategy, inbox distribution, and content best practices — see Email deliverability.